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A member asked:

Why are antihypertensive drugs that act solely by dilating blood vessels not good for long term effectiveness?

A doctor has provided 1 answer

Hypertension: Not all direct vasodilators lose effectiveness with time. The body can accomodate to the peripheral dilation by fluid retention or increased cardiac output. Needing more than one antihypertensive medication is not unusual.

Answered 7/16/2013

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