I ran a drug-drug interaction analysis for these medications and there is no interaction. They are safe to take together. Ensure you avoid alcohol use while on flagyl -- severe GI distress happens when they are mixed. Sertraline, like many SSRIs, can cause GI symptoms like nausea and diarrhea, by nature of its serotonin effect, especially at first. Starting at a low dose can help avoid this.
Answered 8/9/2023
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