A member asked:

I am about to start methotrexate for my rheumatoid arthritis and have had genital herpes in the past. how common is the outbreak and how severe is it?

Q: i am about to start methotrexate for my rheumatoid arthritis and have had genital herpes in the past. how common is the outbreak and how severe is it?

: It is not a contraindication for using methotrexate with history of HSV-2 related genital herpes. There is not any reliable study regarding the severity of HSV 2 reactivation with methotrexate use that I have known of. One study recommends NOT checking HSV titers before initiating treatment with methotrexate. Good luck with your treatment.

A doctor has provided 1 answer

Dr. Hiep Le answered

Specializes in Nephrology and Dialysis

It is not a contraindication for using methotrexate with history of HSV-2 related genital herpes. There is not any reliable study regarding the severity of HSV 2 reactivation with methotrexate use that I have known of. One study recommends NOT checking HSV titers before initiating treatment with methotrexate. Good luck with your treatment.

Answered 7/15/2023

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A member asked:

I am about to start methotrexate for my rheumatoid arthritis and have had genital herpes in the past. how common is the outbreak and how severe is it?

A doctor has provided 1 answer

Dr. Hiep Le answered

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