Does kidney disease cause scrotal edema?

Certain types can.: Certain types of kidney disease, like nephrotic syndrome, can lead to tissue edema, often evident in the scrotum. In nephrotic sydrome, loss of protein in the urine due to defects in the kidney podocytes leads to to movement of fluid from the bloodstream into the tissues. Retention of sodium and water worsen the edema, which occurs throughout the body.

Scrotal edema: If a person has heavy proteinuria, low serum albumin, and generalized edema with fluid in the abdominal cavity, then scrotal edema can result. Other kidneys of kidney disease do not typically cause localized fluid retention in the scrotum.