A member asked:

Why is gnrh released in pulses rather than a continual steady stream?

5 doctors weighed in across 2 answers

Different effects: Continuous secretion of gnrh suppresses production of FSH & lh from the pituitary. Pulses of gnrh stimulate production of FSH & lh from the pituitary.

Answered 6/18/2022

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Dr. Seth Derman answered

Specializes in Reproductive Endocrinology and Infertility

Receptors: Gnrh turns on receptors in your pituitary gland which make it release lh and fsh which in turn stimulate the ovaries/testes. It works great when it is released in pulses, but when it is continuous, the receptors are unable to function properly and shut down, so the pituitary acts as if there is no gnrh around. This is how drugs like Lupron (leuprolide) work.

Answered 9/28/2016

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