Is sam e safe? does it cause any weight gain and can i take it with progestin only birth control pills? thanks

SAM e: Supplementation with s-adenosylmethionine (sam-e), has also been promoted as treatment for osteoarthritis. A meta-analysis of rcts (randomized controlled trials) found that sam-e is as effective as nsaids in reducing pain and disability, and has a better safety profile. I did not see any evidence that it causes weight gain. Whether it has any interaction with progestin based ocp's is not known.