Is it okay to take vicodin or better to take t3 (liothyronine) for occasional ache?

Neither: For the occasional pain, take ibuprofen, tylenol, (acetaminophen) or aleve.

Either: There are really no differences between the two medications in terms of pain relief. Just take what works best. The main difference between the drugs is side effects-t 3 may cause more nausea in some people. However, my best advise is take take neither of them. It would be better to take a less strong analgesic and avoid the possibility of becoming addicted.