Not with gel but...: This depends on which part of the plant is used.The inner gel is quite safe, but the skin, used as a laxative, contains anthroquinones that can cause melanosis (though that is not necessarily serious). See http://www.Ibsgroup.Org/forums/topic/158584-why-i-stopped-taking-aloe-vera-juice/ (scroll down-the top part is misleading as the first posters don't get the diff.). Also see http://bit.Ly/19ymyl0.
Answered 3/15/2018
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