Can you take xanax (alprazolam) and oxycodone at the same time?

Xanax (alprazolam): Excess sedation can result, depending on the dosage of each.

Yes: You can take these together, but can cause excessive sedation. This is a combination that is falling out of favor. Make sure your provider has a goal for your treatment and is not just prescribing these medications. You may need to see an interventional pain specialist or another specialist.