Can mutations in certain grandparents cause asperger syndrome in grandchildren?

Unsure what's meant: There is strong evidence that autism and asperger's disorder have genetic component, and it certainly is possible to "skip generations, " so a child with a grandparent who has such a diagnosis is at increased risk. We don't know, though, what genes are involved, let alone if they are mutations.

Possible: Certainly there are genetic tendencies, but they are not commercially available to test. And even if there is a family history there is no way to know for sure that that gene trait will be passed. Some genetic abnormalities are spontaneous mutations.