What can you do immediately for a very painful toothache?

A NSAID: Nsaids like motrin, Aleve (naproxen) and even Aspirin can relieve this pain. Usually toothaches result from an infection near or in the tooth. These infections usually respond to old fashioned penicillin tablets. When you eliminate the cause of the infection, the pain goes away pretty fast. For some people acupuncture is very effective but it doesn't take away the cause of the pain.

See a Dentist: The best thing you can do when you have tooth pain is see your dentist. You can take Ibuprofen to help with the discomfort before you go, but you need to see a dentist.

OTC pain meds: And then call a dentist for an emergency appointment.