Rebound effect zicam sinus relief nasal spray 3 days in a row?

Beware!: Otc decongestant sprays such as zicam, afrin, etc (oxymetazoline) can definitely cause rebound congestion typically after 5 to 7 days of use. This condition is called rhinitis medicamentosa, and long-term use of such medications can be difficult to treat. For severe cases, an allergist or ENT physician can recommend weaning protocols in conjunction with proper rhinitis therapy.