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Rodeo, CA
A 50-year-old male asked:

I take gabapentin 300 mg twice a day for severe bilateral peripheral neuropathy pain. is 900 mg a day safe for kidneys? i'm stage 3, pkd patient.

2 doctor answers9 doctors weighed in
Dr. Djamchid Lotfi
Neurology 59 years experience
Yes : Recent studies suggest that 1800 mg is the most ideal dosage for most purposes naturally if a smaller dosage is working so much the better the drug is not nephrotoxic.
Dr. Jack Rubin
Nephrology and Dialysis 49 years experience
Increase Gabapentin?: Gabapentin (g) toxicity in patients with chronic kidney disease (ckd) is under recognized. Patients with CKD often receive inappropriately high g dosage for their kidney function, occasioning overt toxicity; advanced age and comorbidity predispose CKD patients to toxicity. I would ask your nephrologist's (c) opinion before increasing the dose, as the n knows you the best.
Last updated Mar 21, 2018


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