A 20-year-old male asked:
i am a student of 2nd year in medical . my question is that, that how rheumatic heart disaese causes valvular heart disease?
3 doctor answers
Dr. Elden Rand answered
21 years experience Cardiology
Reference: "pathogenesis of acute rheumatic fever and rheumatic heart disease: evasive after half a century of clinical, epidemiological, and laboratory investigation" http://www.Ncbi.Nlm.Nih.Gov/pmc/articles/pmc1768618/.
Answered on Sep 11, 2013
Dr. Payam Mehranpour answered
23 years experience Cardiology
Inflammation: Rheumatic fever is a systemic disease following strep pyogenes infection. Inflammation of the endocardium and valves lead to significant scarring, fibrosis and destruction of the valve structure and function leading to stenosis and/or regurgitation.
Answered on Sep 6, 2013
32 years experience Internal Medicine
It is immunological: This is an immune complex deposition on the valves mainly the mitral valve . The m protein in the streptococcus and the myocardial tissue has cross reaction . The immune system attacks the strept bacteria as well as the myocardial tissue . The process trigger inflammation and destruction of tissues , scarring and redundancy . The commonest valvular abnormality is mitral stenosis
Answered on Sep 9, 2013
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