Which heart diseases leads to valvular heart disease?

See below.: In the past rheumatic fever was an important cause of valvular heart disease. Today ageing is a common cause of valvular disease such as aortic stenosis. Drug abuse can result in valve damage due to bloodstream infection called endocarditis. Untreated high blood pressure can cause enlargement of the heart and leakage of the valves.

Coronary disease/CAD: CAD can lead to weakened or poorly functioning heart muscle. The mitral valve is anchored to that muscle and will leak if CAD is severe enough. Rheumatic heart disease can lead to valve stenosis due to calcification, but has become less likely in the era of antibiotics. Also, being born with a bicuspid aortic valve (normally 3 cusps) can lead to calcification and narrowing at 50-60 years of age.