Mostly: If you are not taking other medications and use proper doses, these may be safe. Both are sedating and can cause reactions or possible allergy. Valerian root may cause disturbed dreams and other side effects. Kava has been associated with liver toxicity which may be due to the wrong part of the plant being used. Use trusted sources that use the right part. Kava root not stem or leaf.
Answered 7/30/2020
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