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A member asked:
Can glutamate rebound occur with other glutamate antagonists such as ketamine? or just with alcohol?
5 doctors weighed in across 2 answers
Why do you ask?: Ketamine is a highly dangerous controlled substance, and its use outside of strict medical supervision is illegal and potentially lethal. Your point about alcohol & glutamate is notable for explaining why alcohol is not a good choice for sleep-induction.
Answered 3/29/2014
4.9k views
Hang over: Ketamine does not usually result in glutamate rebound symptoms (hang over) when used as an anesthetic. For those who chronically abuse ketamine as an illegal drug, glutamate rebound is likely to take place.
Answered 2/1/2015
4.9k views
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