A member asked:

Can glutamate rebound occur with other glutamate antagonists such as ketamine? or just with alcohol?

5 doctors weighed in across 2 answers
Dr. Darrell Herrington answered

Specializes in Family Medicine

Why do you ask?: Ketamine is a highly dangerous controlled substance, and its use outside of strict medical supervision is illegal and potentially lethal. Your point about alcohol & glutamate is notable for explaining why alcohol is not a good choice for sleep-induction.

Answered 3/29/2014

4.9k views

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Dr. John Sampson answered

Specializes in Anesthesiology

Hang over: Ketamine does not usually result in glutamate rebound symptoms (hang over) when used as an anesthetic. For those who chronically abuse ketamine as an illegal drug, glutamate rebound is likely to take place.

Answered 2/1/2015

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