Does ketamine cause glutamate rebound?

Not sure: Ketamine functions in the brain as a “dissociative anesthetic, ” where dissociative indicate a shutting off of the brain from the body rather than simply pain blocking. Specifically, ketamine blocks the brain’s glutamate receptor, which when normally functioning accept glutamate increasing cell activity and brain function. I have not seen any evidence of glutamate rebound, but will research.

Ketamine - Glutamine: Most research on ketamine - glutamine interactions has been done on rats. Alcohol inhibits glutamine release. As the alcohol us metabolized, glutamine is released and one can not sleep well, contributing to a "hangover". Ketamine inhibits glutamine receptors and also inhibits release of nitric oxide. This inhibition is crucial for production of anesthesia. No more can be concluded now.

Unlikely: With long term usage (like michaeljackson) it could be possible that the receptors would upregulate (increase innumber) and thus rebound.