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A member asked:
Does every receptor in the brain and binding site in the brain have or once had during evolution and endogenous ligand?
5 doctors weighed in across 2 answers
Probably yes: Parsimony in resource use would suggest the answer is "yes". However, development of receptors solely for exogenous ligands is possible. Not sure if that has been proven.
Answered 8/31/2013
4.9k views
Thank
Yikes: The standard reference for those interested in such questions is The Biochemical Basis of Neuropharmacology by Cooper, Bloom and Roth. Wishing you good reading.
Answered 5/22/2016
3.7k views
Thank
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