Double question: The active metabolite has an elimination half-life of about eight hours. Following an oral dose of 14c-labeled clopidogrel in humans, approximately 50% was excreted in the urine and approximately 46% in the feces in the five days after dosing. Because Plavix works by irreversibly inhibiting a receptor on platelet cell membranes, the effect of the drug will linger even though the drug is gone.
Answered 11/10/2018
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