A member asked:

Would side effects be present with increasing zoloft (sertraline) dosage of 25 to 50mg? although no bad side effects when taking 25mg, but many with 50mg.

7 doctors weighed in across 3 answers

Yes: Dose increases blood level and this could tip the balance with the other medications.

Answered 7/28/2016

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Yes: Side effects are more commonly seen with increased doses of this medicine.

Answered 7/7/2015

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Dr. Alan Koenigsberg answered

Specializes in Psychiatry

Maybe: In my practice, i start most adults on zoloft (sertraline) at 50 mgs daily, and they do well. I then have them increase the dose to 100 - 200 mgs gradually, so they can be at a therapeutic dose. If you are having side effects now, see your physician and discuss all of your medications, over the counter medicines, and concerns. It may be that your side effects are due to medication interactions.

Answered 4/15/2017

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