Athens, GA
A 22-year-old female asked:
Would side effects be present with increasing zoloft (sertraline) dosage of 25 to 50mg? although no bad side effects when taking 25mg, but many with 50mg.
3 doctor answers • 7 doctors weighed in

Dr. Toner Overleyanswered
Psychiatry 75 years experience
Yes: Dose increases blood level and this could tip the balance with the other medications.
Created for people with ongoing healthcare needs but benefits everyone.
4.9k viewsReviewed >2 years ago

Dr. Laura Larchanswered
21 years experience
Yes: Side effects are more commonly seen with increased doses of this medicine.
Created for people with ongoing healthcare needs but benefits everyone.
4.9k viewsAnswered >2 years ago

Dr. Alan Koenigsberganswered
Psychiatry 44 years experience
Maybe: In my practice, i start most adults on zoloft (sertraline) at 50 mgs daily, and they do well. I then have them increase the dose to 100 - 200 mgs gradually, so they can be at a therapeutic dose.
If you are having side effects now, see your physician and discuss all of your medications, over the counter medicines, and concerns. It may be that your side effects are due to medication interactions.
Created for people with ongoing healthcare needs but benefits everyone.
4.9k viewsReviewed >2 years ago

Dr. William Marchand commented
Psychiatry 37 years experience
Usually lower doses, such as 50 mg/day don't cause side effects - but there is a lot of individual variation.
Sep 13, 2013
Last updated Apr 15, 2017
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