1leg weakness: The most common cause of weakness and atrophy in 1 leg would be a chronic herniated disk in the spine, which has gone on long enough to damage the nerve. If so, this would be an indicated for surgery. Other spinal cord lesions could do it also--tumor, clot, infection, vascular malformation. How long has it been going on? Was there any pain? Any tingling? Any other symptoms?
Answered 5/8/2019
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Nerve damage: If you have unilateral muscle weakness and atrophy there has to be an injury or impingement of the nerve which innervates that part of your leg. A demyelinating process such as MS may also lead to muscle atrophy and weakness unilaterally. Other causes may be trauma to that muscle, prolonged immobilization in a cast, or not weight bearing on the leg can lead to loss of strength and muscle mass.
Answered 1/19/2019
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