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A 36-year-old male asked:

Why avascular necrosis in sickle cell disease involve long bone only?

2 doctor answers7 doctors weighed in
Dr. Michael Dugan
Specializes in Hematology
The ends of : The long bones have the most tenuous blood supply, and thus are at the greatest risk.
Dr. Louis Cooper
Pediatrics 48 years experience
Actually all bones are at risk--tiny microcapillaries can be damaged by red cells in sickled form can block these vessels --this can be seen in vertebrae of back, neck areas too.
Aug 15, 2013
Dr. Craig MacArthur
Pediatric Hematology and Oncology 34 years experience
Not only long bones: Sickle cell avn can occur in any bone that has limited blood supply. The obstruction to blood flow caused by sickle cells can cause the bone to die and distort normal shape and function, causing pain. The head of the femur (a long bone) and the talus bone (not long bone) in the ankle are common sites of avn in my sickle cell patients.

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Last updated Nov 28, 2017

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