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A 38-year-old member asked:

The increased risk of having a child with genetic defects like down syn. also applies to men over age 40?

1 doctor answer2 doctors weighed in
Dr. Sarosh Batlivala
Pediatric Cardiology 17 years experience
Yes: The simple answer is yes, but for different and incompletely understood reasons. "advanced paternal age" has been associated with genetic defects in general, though not specifically Down syndrome as in women. The reasons remain to be determined, but as with anything else, scientific literature suggests that sperm "quality" degrades over time with increased risk of various defects.
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Last updated Feb 18, 2015

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