What could cause secondary (acquired) immunodeficiency coupled with autoimmunity? both started at same time. cancers and infections?(negative 4 hiv)

Immunity: In some cases the immune itself turns on its host and causes autoimmune diseases, and in some of those cases the immune defenses are affected and lead to an immune deficiency. The cause remains a mistery, hypotheses abound, some say it is triggered by an infection but the proff is elusive. You need a rheumatologist and immunologist to assist you with your answers.

Immune Dysregulation: Disruption of the process of self/non-self recognition can lead to either immune deficiency (increased susceptibility to infection) or to autoimmunity (increased and pathogenic responses to self-antigens). Many of the genes that create susceptibility to autoimmunity also create susceptibility to immune deficiency.