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A 25-year-old male asked:

How do ace inhibitors reduce proteinuria with regard to nephrin levels?

2 doctor answers3 doctors weighed in
Dr. Addagada Rao
General Surgery 57 years experience
B P control : Angiotensin coverting enzyme (ace ) inhibitors will control the blood pressure , there by preventing excessive filtration of protein mainly Albumin , and better reabsorption at nephran level there by reducing the protein loss , the loss is usually over 300 mg per day
Dr. Jack Rubin
Nephrology and Dialysis 49 years experience
Proteinuria and ACE: Ace-inhibtors reduced proteinuria (p) by reducing the vasoconstriction caused by angiotensin ii on the efferent arteriole (ea) of the glomerulus. Once this pressure is reduced, there is less back pressure in the glomerulus, thereby reducing the amount of p the patient has. Other agents, such as angiotensin receptor blockers can also do the same thing.

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Last updated Apr 12, 2020

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