U.S. doctors online nowAsk doctors free
Washington, DC
A 26-year-old female asked:

Does low serum globulin affect blood tests that assess immunoglobulin levels? for example if an illness caused proteinuria, could a disease actually cause the test for it to be falsely negative?

2 doctor answers2 doctors weighed in
Dr. Marsha Davis
Internal Medicine 29 years experience
If I follow you: If you have low proteins and then get a disease that causes protein in your urine, could a test be falsely negative ? Well a smart doc would know to order quantitative protien and then it could be interpreted in light of known low immunoglobulins . Some people always spill small amounts of protein, most do not. Doc must know this info too. It's complicated.
Created for people with ongoing healthcare needs but benefits everyone.
Dr. John Chiu
Allergy and Immunology 58 years experience
Depends: If your immunoglobulin(s) is low especially when it involves igg, your immune system is likely impaired. It is not a "false-postive" result although the cause for the deficiency may vary and treated accordingly.
Created for people with ongoing healthcare needs but benefits everyone.
Last updated Sep 11, 2016

Disclaimer:

Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. Never disregard or delay professional medical advice in person because of anything on HealthTap. Call your doctor or 911 if you think you may have a medical emergency.