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Chatham, NJ
A 24-year-old female asked:

What can i expect during the first week on zoloft (sertraline) 25 mg? do side effects like upset stomach headaches start right away? worried

1 doctor answer2 doctors weighed in
Dr. Pamela Pappas
Psychiatry 43 years experience
Zoloft (sertraline): You may not notice anything at all in the first week, . Side effects like upset stomach are common, but not everyone experiences them. In preclinical studies, 25% of zoloft (sertraline) users had nausea compared to 10% of those on placebo. With headache, 25% of zoloft (sertraline) users had this compared with 23% on placebo. So, the majority of people tolerate zoloft (sertraline) well -- & it needs 6-8 weeks to see positive effect.
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Last updated Mar 6, 2020


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