A 45-year-old member asked:
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what causes agenesis of the corpus callosum?

4 doctor answers
Dr. Matt Wachsman
36 years experience Internal Medicine
Congenital: abnormality. Born with it. Callosal malformations are among the most common congenital brain anomalies and are associated with a wide range of neuropsychological deficits
Answered on Nov 30, 2014
Dr. Silviu Pasniciuc
27 years experience Internal Medicine
Unknown cause: Etiology remains largely unknown. It seems to be related to inherited conditions, metabolic disorders, or exposure to toxins or viruses in the first trimester that affect normal fetal development.
Answered on Nov 30, 2014
Dr. Visalakshi Vallury
24 years experience Family Medicine
Birth defect: Agenesis of the corpus callosum (ACC) is a rare birth defect (congenital disorder) in which there is a complete or partial absence of the corpus callosum.. This likely occurs in the first trimester but the exact cause cannot be known. ACC can cause problems with facial recognition, processing of complex information, vision impairment, poor muscle tone etc. There is no specific treatment.
Answered on Jan 8, 2015
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Dr. Michael Gabor
33 years experience Diagnostic Radiology
It is a: developmental congenital abnormality, occurring in isolation or in association with various cerebral abnormalities/syndromes.Agenesis of the corpus callosum is caused by disruption to development of the fetal brain between the 3rd and 12th weeks of pregnancy. In most cases, it is not possible to know what caused an individual to have ACC.
Answered on Dec 1, 2014

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A 37-year-old member asked:
Dr. Bert Liang
Specializes in Neurology
Rare: It is very rare for individuals to be born with either agenesis or partial agenesis of the corpus callosum. It can also be associated with other gene ... Read More
A 39-year-old member asked:
Dr. Mark Roberts
42 years experience Family Medicine
Rare, variable six.: I would refer you to the ACC page on: www.rarediseases.org, the website of NORD, the National Organization for Rare Disorders. A very helpful & in ... Read More
A 36-year-old member asked:
Dr. Vered Lewy-Weiss
A Verified Doctor answered
A US doctor answered Learn more
Mid-line defect: Agenesis of the corpus callosum may be associated with other brain abnormalities. How a child would be with agenesis of the corpus callosum depends o ... Read More
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A 38-year-old member asked:
Dr. Marilynn Frederiksen
47 years experience Maternal-Fetal Medicine
Partial agenesis: A fetal MRI can confirm what we see on ultrasound and may be helpful in prediction. Chromosomal analysis, usually by amniocentesis, is also important. ... Read More

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