A 49-year-old male asked:
Alt high 60, AST high 45 on methotrexate 25mg, arava (leflunomide) 20mg, enbrel weekly. Should i be concerned? Never had pblm.
1 doctor answer
Dr. Ronald Krauser answered
51 years experience in Rheumatology
Maybe: I, personally am not a big fan of using Methotrexate and Arava (leflunomide) in combination because of the increased risk of liver toxicity. Your enzymes are only mildly elevated but i would talk to your rheumatologist about reducing dosages or eliminating one of the meds altogether.
Answered on Jun 28, 2014
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