A 30-year-old male asked:
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can a mother with enough high testosterone during pregnancy make an xxy or xx(with sry gen) a male who will become fertile after puberty?

1 doctor answer
Dr. Vered Lewy-Weiss
27 years experience Pediatrics
No: Testosterone will only virilize a fetus (and the mother). Genetics determine fertility in terms of the karyotypes mentioned. Both of these karyotypes (+sry) typically produce males with normal appearing genitalia.
Answered on Jul 14, 2013
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Dr. Liuska Pesce
22 years experience Pediatric Endocrinology
However, those karyotypes, will likely have fertility problems
Jul 14, 2013

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Xxy male: Probably below that if any.
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Karyotype: A simple chromosomal test called a karyotype can rule out klienfelter syndrom.

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