I have had 2 early losses and 1 2nd trim. (pprom) loss and am ttc now. i have mthfr and pai-1, could this be interfering with conception?

Probably not: The mthfr gene mutation and pai 1 abnormality is usually related to recurrent pregnancy loss and is usually treated with low-dose aspirin, heparin, and increased doses of folic acid, vitamin b6, and vitamin b12. These abnormalities are usually not related to the failure of conception.

Perinatologist: You should see a maternal fetal medicine specialist prior to conception to ensure that everything that can be done is done to maximize your chances of a term delivery.

It could: Actually, having a positive mthfr mutation can interfere with conception because the mthfr enzyme that converts homocysteine to another protein. If there is a deficiency in that enzyme, for is a buildup of homocysteine in your blood stream and elevated levels of homocysteine can be associated with micro-clotting which could cause an early pregnancy loss between ovulation and your menses.