A 34-year-old female asked:
I have had 2 early losses and 1 2nd trim. (pprom) loss and am ttc now. i have mthfr and pai-1, could this be interfering with conception?
3 doctor answers • 6 doctors weighed in
Fertility Medicine 40 years experience
5k viewsReviewed >2 years ago
Obstetrics and Gynecology 30 years experience
5k viewsAnswered >2 years ago
Fertility Medicine 45 years experience
It could: Actually, having a positive mthfr mutation can interfere with conception because the mthfr enzyme that converts homocysteine to another protein. If there is a deficiency in that enzyme, for is a buildup of homocysteine in your blood stream and elevated levels of homocysteine can be associated with micro-clotting which could cause an early pregnancy loss between ovulation and your menses.
4.9k viewsAnswered >2 years ago
Last updated Sep 14, 2013
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