Confusing question: There are thousands of genetic issues and each has it's own explanation. For some they represent spontaneous new mutations in genes, for some a random chromosome defect. Some represent the result of two parents that carry the silent but abnormal gene in an asymptomatic state and by passing an abnormal gene from both parents, have a kid that is symptomatic.More specific questions can get more info.
Answered 8/24/2017
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