A member asked:

If you combined h1 and h2 anti-histamines, could this prevent anaphylaxis?

3 doctors weighed in across 2 answers
Dr. Michael Zacharisen answered

Specializes in Allergy and Immunology

Not necessarily: H1 and h2 antihistamines are used for the treatment of anaphylaxis in addition to Epinephrine and steroids. Preventing anaphylaxis is challenging--best way is to avoid the trigger. In those cases where no trigger is found and anaphylaxis is occurring frequently, Prednisone (steroids) will be used on a daily basis. This carries a high risk of side effects however.

Answered 5/6/2015

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Dr. Luis Matos answered

Specializes in Pediatric Allergy and Asthma

Maybe-not guaranteed: Many different combinations of medications have been studied. Antihistamines (Histamine 1 blockers), Histamine 2 blockers (ranitidine, cimetidine or famotidine) some will also add anti leukotrienes (montelukast, Zafirlucast) Keep your epinephrine injector close by. If you qualify, the NIH is studyingAnaphylaxis http://www.niaid.nih.gov/volunteer/idiopathicanaphylaxis/Pages/default.aspx

Answered 5/6/2015

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