Urine drug test : Benadryl (diphenhydramine) may cause a false positive drug test to Methadone in screening urine drug test but there are no reports of Claritin / zyrtec / allergra being a problem. However, Claritin d, zyrtec d, allergra d may cause positive drug test to amphetamine since they contain pseudonephrine.
Answered 6/28/2014
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