Is it safe to take lunesta (eszopiclone) 3mg and ambein 6.5mg long acting together ?

Who knows/ best not: There are no systematic studies of the 2 together. So, in one sense - who knows! however, if a recommendation is to be made on the basis of clinical reasoning, i would say it makes no sense to combine these 2 medications, and a person doing so better be ready for s/e that they may not experience on either one alone. Hope this helps.