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Riverview, MI
A 62-year-old female asked:

does sam-e help with mild depression and anxiety?

2 doctor answers7 doctors weighed in
Dr. Pamela Pappas
Psychiatry 42 years experience
Yes, it may: Sam-e may help in depression. One study used sam-e as an augmentation strategy for people who did not respond to ssri's. Remission rates were slightly higher in the adjunctive sam-e group than placebo. http://www.ncbi.nlm.nih.gov/pubmed/20595412?dopt=abstract also sam-e has been found effective for depression on its own. http://www.ncbi.nlm.nih.gov/pubmed/12418499?dopt=abstract.
Dr. Michael Rockwell
Psychiatry 33 years experience
Yes, but....: In my experience 'yes'; in europe it is prescribed for such. However here in the states is it not monitored/it's a supplement. So it is difficult to gauge how much to take. Most of the time it is too expensive to pay out of pocket to use.

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Last updated Feb 27, 2017

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