Does accutane lead to increased temper loss?

That is a possible : Side effect. Per drugs.Com: psychiatric side effects have included depression, nervousness, psychosis, aggression, violent behaviors, emotional instability, suicidal ideation, suicide attempts, and suicide.".

Possibly: Mood changes in people on isotretinoin are a subject of some concern. The medicine isn't for the faint-hearted, but clears acne, which when severe is a terrible social and professional liability. The prescribing physician is familiar with the side-effect profile. Acne itself is stressful -- people are likely to treat you differently if you're disfigured -- and temper loss is part of being a teen.