A member asked:

How is it possible my serum iron can be elevated and my ferritin be low at the same time?

2 doctors weighed in across 2 answers
Dr. Milton Alvis, jr answered

Specializes in Preventive Medicine

Easy: 2 Diff Issues: Look up on net: ferritin=complex protein which stores iron atoms inside all cells. Serum iron=iron circulating via transferrin binding proteins in blood plasma. Like most/all lab/medical tests: just sample tiny pieces of what is happening at 1 instant; regard as only clues & ea prove nothing per-se. Mcv on cbc, se fe, s. Ferritin, TIBC (transferrin), bm bx, along with hx bld loss are common clues.

Answered 6/10/2014

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Fluctuations: Serum iron is sensitive to diet, supplements, injury and a host of day-to-day variables. Low serum ferritin is usually a more reliable indicator of available stores, and if mine were quite low, i'd be looking for why i might be losing iron / bleeding rather than have the serum iron think i'd been misled.

Answered 6/8/2013

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