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Lake Charles, LA
A 33-year-old female asked:

Can the duodenum appear normal visually but have biopsies come back positive for celiac disease?

1 doctor answer3 doctors weighed in
Dr. Charles Cattano
Gastroenterology 40 years experience
Yes...: Celiac disease is often "patchy", so that multiple biopsies (four to six) at various duodenal sites are needed to accurately identify the entity. As such, some parts of the duodenum may visually appear relatively unremarkable. Also, gluten avoidance may result in a normalized small bowel lining prior to diagnostic biopsies.
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Last updated Jun 21, 2020


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