A member asked:

Can the duodenum appear normal visually but have biopsies come back positive for celiac disease?

A doctor has provided 1 answer
Dr. Charles Cattano answered

Specializes in Gastroenterology

Celiac disease is often "patchy", so that multiple biopsies (four to six) at various duodenal sites are needed to accurately identify the entity. As such, some parts of the duodenum may visually appear relatively unremarkable. Also, gluten avoidance may result in a normalized small bowel lining prior to diagnostic biopsies.

Answered Jun 21, 2020

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