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A 22-year-old male asked:

What is hemoglobin j? does it have any relationship with alpha thalassemia?

2 doctor answers4 doctors weighed in
Dr. Ed Friedlander
Pathology 46 years experience
Mutated: This is a group of mutated hemoglobins that travel fast on electrophoresis. Most are non-problems. Unlike in the thalassemias, in which the portion of the gene that determines whether the chains get transcribed and translated, here the mutation is in the chains themselves. Your physician can tell you more about which "j" you happen to have. Best wishes.
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Dr. Michael Engel
Pediatric Hematology and Oncology 22 years experience
Uncertain: Hemoglobin j is actually a group of at least 50 variants that share a common rapid mobility in electrophoresis and ief. Mutations can occur in either the Alpha or beta chains. Most oftenpresent in the heterozygous state and clinically silent. Because of this, and the limited information about them in relation to other abnormal hemoglobins, a relationship with thalassemia syndromes is not known.
Created for people with ongoing healthcare needs but benefits everyone.

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Last updated Mar 11, 2020


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