A member asked:

Please help, i have pustular psoriasis on my feet dr wants me to try methotrexate or enbrel (etanercept). what are those meds?

3 doctors weighed in across 2 answers
Dr. Robert Lowe answered

Specializes in Pediatric Rheumatology

Highly effective med: Psoriasis is an autoimmune disease involving the white blood cells attacking the skin as if it was bacteria or a virus. Low dose weekly Methotrexate is very effective in treating psoriasis--the way it works is not completely understood but decades of use show it's a reliable and safe drug (no alchohol! while taking). Enbrel (etanercept) is a newer highly effective drug that neutralizes tnf, inflammatory protein.

Answered 6/28/2014

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See details: Methotrexate is an anti-inflammatory with some immunosuppressive properties and Enbrel (etanercept) is a tnf agent. Both are very effective for psoriasis, especially the enbrel (etanercept). They both have risks with infection the greatest one for enbrel (etanercept).

Answered 6/28/2014

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