I have ms and can no longer use enbrel (etanercept) which worked great for my psoriasis....i started methotrexate 3 weeks ago and no real change yet, any ideas?

Patience: It usually takes a bit longer to start seeing an effect. You should be prepared for it to take 2-3 months.

Give it time: Methotrexate takes time to work and it usually works best for psoriasis in the 20-25 mg weekly range.

Suggestion: You possess a complex problem which afflicts several patients; i.e., two automimmune disorders. This creates a need to have very coordinated care from both a neurologist and a dermatologist, and you are advised to get a consult or two from a local medical school. The Methotrexate may yet work, as could take a few more weeks, but you may want to modify your ms medicine if needed.