A member asked:

I have ms and can no longer use enbrel (etanercept) which worked great for my psoriasis....i started methotrexate 3 weeks ago and no real change yet, any ideas?

5 doctors weighed in across 3 answers
Dr. Arlo Miller answered

Specializes in Dermatology

It usually takes a bit longer to start seeing an effect. You should be prepared for it to take 2-3 months.

Answered May 28, 2016

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Dr. Ronald Krauser answered

Specializes in Rheumatology

Methotrexate takes time to work and it usually works best for psoriasis in the 20-25 mg weekly range.

Answered Jun 28, 2014

5.3k views

Thank
Dr. Bennett Machanic answered

Specializes in Neurology

You possess a complex problem which afflicts several patients; i.e., two automimmune disorders. This creates a need to have very coordinated care from both a neurologist and a dermatologist, and you are advised to get a consult or two from a local medical school. The Methotrexate may yet work, as could take a few more weeks, but you may want to modify your ms medicine if needed.

Answered Jun 28, 2014

5.3k views

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