Do you ever diagnose systemic sclerosis sine scleroderma and if so, what are the the clinical signs and symptoms of this disease?

Internal : Systemic sclerosis sine scleroderma would have some positive autoantibodies such as ANA on lab work and may involve only internal areas such as the esophagus or lungs. Difficulty with swallowing may be seen. See a rheumatologist for a full work up, evaluation and treatment.

Extremely rare: Systemic sclerosis sine scleroderma is a fibrosing condition of the internal organs including the GI tract, pulmonary artery, and lungs, but lacking the skin features if scleroderma. Systemic sclerosis is a rare condition to begin with, and systemic sclerosis sine scleroderma accounts for <10% of patients. Diagnosis might include antibody tests or abnormal biopsy of affected internal tissues.