Can anti-seizure medication contribute to melasma?

Melasma: Yes, anti-seizure medications can contribute to the development of melasma.

Hyperpigmentation: Anticonvulsants can potentially cause melasma. A number of anticonvulsants can cause photosensitivity, an increased response of the skin to the sun, which would make sun-exposed skin tan or burn faster. Anticonvulsants, particularly phenytoin, can also cause drug-induced hyperpigmentation. It is very important not to stop your anti-seizure meds regardless of whether or not they may cause melasma.