A member asked:

Which pain-causing diseases/disorders cause malfunction in transient receptor potential cation channels of subclass a type (trpa1)? autoantibodies?

A doctor has provided 1 answer

TRPA1 Gene Family: The best article i've read on this gene family is ===> http://www.Genecards.Org/cgi-bin/carddisp.Pl?Gene=trpa1. The clinical significance of mutations in this gene has been related to caffeine and nicotine sensitivity disorders, and rare environmentally-triggered pain disorders. The complete function of this gene family is not known.

Answered 9/5/2013

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