Roughly how long after taking st john's wort until it takes effect?

Severity counts: St. John's wort is effective for mild to moderate (not severe) depression. It needs to be taken at 300mg 3 times daily for 4-6 weeks for effect -- similar to antidepressants. Use a product standardized to .3% hypericin extract -- some are also standardized to 2-5% hyperforin as well. St. John's wort may precipitate mania just as antidepressants can do. Do not take with antidepressants.