A member asked:

When i have my daughter tested for brca gene? my husband's sister was diagnosed with stage 3 breast cancer. no other history of b.c. in our families.

9 doctors weighed in across 4 answers
Dr. George Klauber answered

Specializes in Pediatric Urology

Good idea: Always better to know than remain in ignorance. She can always get bc advice if brca gene testing ispositive.

Answered 2/25/2012

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Not yet: I am sorry to hear about your sister-in-law. In general, when we are concerned about the hereditary form of breast cancer, we test the affected person first. If they don't harbor the gene, there is no need to test anyone else. Keep in mind that 85-90% of all breast cancer cases are not hereditary. Even if your sister-in-law has the gene, your husband has a 50% chance as well, and your daughter 25%.

Answered 12/9/2013

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Not just yet: A single person with breast cancer in the family is not generally considered a reason for brca testing. A history of multiple indviduals with breast or ovarian cancer or both is usually required. Onset of cancers at an early age and breast cancer in male family members are also important. If your doc feels there is risk you and your daughter should receive genetic counciling before tests are done.

Answered 6/24/2013

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Dr. Carlos Encarnacion answered

Specializes in Medical Oncology

Not now: If your sister in law had cancer before age 45 or had a triple negative cancer before age 60, she fits nccn criteria for brca testing even without family history. She needs to test first and if positive, your husband should test and if he is positive, then you test your girl. Cancer can jump an individual but the gene cannot. Hope all goes well with all in the family.

Answered 6/26/2013

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