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A 58-year-old member asked:

Taking entacort to treat crohn's disease. does this steroid enter bloodstream or only 'topical' within the intestine?

2 doctor answers4 doctors weighed in
Dr. Jason Hemming
Gastroenterology 17 years experience
Both: It acts locally but then it is completely absorbed by the intestine. Following this 80-90% is metabolized by the liver before it reaches the rest of the body (1st pass). However some systemic effect still occurs.
Dr. Ihor Zakaluzny
General Surgery 38 years experience
Minimal absorption: Very little is absorbed, so that systemic side effects are unlikely.

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Last updated Oct 3, 2016
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