Can long term use of hyzaar (losartan and hydrocholorthiazide) cause permanent swelling in legs?

Not from Hyzaar (losartan and hydrocholorthiazide): Hyzaar (losartan and hydrocholorthiazide) is a combination of a diuretic/water pill and an angiotensin receptor blocker/arb which is used to lower blood pressure. The constant leg swelling may mean you are retaining fluid and need a higher dose of diuretic. The arb component has a 1-3% chance of causing angioedema, episodes of swelling involving various parts of the body (unusual to only affect legs) for 24-72 hr not constantly.